postr/StutterFebruary 22, 2026

Anybody tried a NMDA receptor antagonist before?

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Anybody tried a NMDA receptor antagonist before? This is a long shot but I’m curious if anyone here has ever tried taking an “low affinity” NMDA receptor antagonist for speech or fluency issues such as memantine. These are mostly marketed for dementia patients but they usually improve their speech fluency to some degree so it got me thinking about it. From what I gathered, they work by modulating glutamate signaling by reducing excessive background excitation in circuits that are associated with speech and stress so in theory I thought it might work since my speech is worsened under stress. Just curious if anybody has tried this yet to save my embarrassment from asking doc for dementia meds lol.

Themes

Meds & SubstancesAnticipation & AvoidanceCauses & Variability

Subthemes

Medication InquiriesOverthinking & MonitoringStress & Fight/Flight

Codes (1)

dopamine_antagonists_antipsychotics