I've never really cycled while on 5-htp. I've never truly stopped taking 5-htp. Sometimes I'll skip a day or two if I'm feeling great and the 5-htp isn't needed, but those days are rare. There are some ppl on reddit who say that we need to cycle, but drs don't tell people on prozac or other SSRIs to cycle either, and I would argue that 5-htp is safer than those prescription drugs. My best advice is to listen to your body. If something doesn't feel right, then stop taking 5-htp and see if it makes a difference. If you're feeling better than usual, then maybe skip a dose to see if you drop below your baseline. Also, my advice is to buy the 5-htp without any extras (eg, without B-6). From my research, you want the 5-htp to cross the blood-brain barrier and then convert to serotonin in the brain. However, if you take it with B-6, then it starts to convert to serotonin in the gut.