I think it'll still help you. I was also taking one with b6 and it still worked, but I switched to one without b6 after learning about it. My guess is that 5htp without b6 might work better? Nowadays it works pretty quick; I take it before bed and it works by the time I wake up - so maybe give it at least 3 hrs to work. I first tried 5htp almost 21 years ago so I don't remember the specifics. I took it mainly for depression but noticed increased fluency as a side bonus and then did more research on it. I don't think 5htp requires any buildup in the body, but to be on the safe side, maybe give it a week or two.