Experiences tend to get pretty intense at times and your sense of reality can get fairly warped. So it's best to first experience them in a safe, comfortable, familiar place with highly trusted friends or associates who either trip with you or act as your trip sitter. The old phrase "set and setting" is about getting yourself in the best situation to be prepared for a trip. If you or your family has a history with mental illness, I'd be especially cautious and even consider avoiding the experience as in some cases the trip can exacerbate latent or underlying issues that can lead to mental breaks, psychosis, etc. Definitely can be a very beautiful, super illuminating experience though and can help a great deal with self acceptance and an overall sense of love and oneness.