Well, second generation antipsychotics are already used for a whole bunch of off-label conditions, for better or for worse. Most researchers believe that extrapyramidal side effects are much less likely with second generation antipsychotics. Though some say they haven't been around long enough to know, and others say they already know there's still a real risk....Weight gain is probably less likely on the low doses that Maguire is talking about. BUT, yeah, these are hardcore drugs that can have plenty of side effects beyond what you mention here. For many people using these drugs for on-label psychiatric reasons or other off-label conditions, it's a balancing act; are the side effects worth it, *if* the drug is even doing what it's supposed to? Almost all side effects will go away if the drug is discontinued. (But if you have schizophrenia, you pretty much have to be on one of these drugs, side effects or not. Sucks. And, believe me, I know one can have an adverse reaction that can change your life indefinitely. It's rare, though.) You say you would probably never try one no matter how bad your stutter is. But there are people for whom the risk, or the trade off, is worth it. If you're not able to live a life that makes you want to be alive, it's not crazy to try a drug, even a serious drug like one of these, as long as you understand what you're doing. (I recently said this in another thread on here, but I'll repeat: I personally have had bad experiences with psychiatric drugs, plus they never did what they were supposed to do for me. I have a bias against them. But I know that for some people -- millions -- they are life savers. So I try not to be dismissive. As far as using them to treat stuttering, I don't know, it doesn't seem any stranger to me than using them to treat other conditions that seem possibly connected to chemical imbalances in the brain. Obviously, not much study has been done with these drugs and stuttering. But the truth is they hardly know anything about the disorders these drugs were supposedly designed for, nor do they acknowledge their true efficacy rate [uh, lower than they say] nor the full impact of side effects. In some ways it's even worse with anti-depressants, particularly when it comes to withdrawal problems, but I'm digressing now...) Edit: a typo