It always depends a lot on what's your mindset and the setting you are in when you take them. Personally I think when paired with psychotherapy, or even just you learning online about things related to mental health and spirituality, it boosts the benefits by a lot. Yeah it's better to increase slowly eheh, it can be very frightening if you jump to a big dose. I've heard that story too ahah I guess it could happen. It causes you to question everything you've learned, making new associations and yeah kind of rewiring your brain. Super helpful in my opinion